| Yu Albert Cheung Hoi | 20-Dec-21 | | INED | | |
| Ung Monin | 20-Dec-21 | 01-Dec-25 | INED | | Ms. Ung wishes to devote more time to decentralized life science and to expanding her law offices in China. Ms. Ung will remain as an advisor to the Company after her resignation. |
| Ung Monin | 20-Dec-24 | 01-Dec-25 | Ch | | Ms. Ung wishes to devote more time to decentralized life science and to expanding her law offices in China. Ms. Ung will remain as an advisor to the Company after her resignation. |
| Cheung Hoi Yu | | 18-Oct-25 | INED | | Dr. Yu wishes to devote more time to his other commitments. |
| Zhang Jiankang | 12-Jul-21 | 21-Jun-25 | Non-Executive Director | | Mr. Zhang wishes to devote more time to his family and other commitments. |
| Dr. Yang Lu (Alias Patrick Lu) | | 23-Apr-25 | Honorary Scientific Advisor of the Group, All positions of Sirnaomics Biopharmaceuticals (Guangzhou) Co., Ltd., All positions of Sirnaomics Biopharmaceuticals (Suzhou) Co., Ltd., All positions of Sirnaomics, Inc. | | The Cessation allows the new management team room to focus its efforts on stringent internal control measures and on regulatory compliance. |
| Dr. Yang Lu (Alias Patrick Lu) | | 05-Feb-25 | Non-Executive Director | | Dr. Lu wishes to devote more time to his other commitments. |
| Huang Mincong | 25-Jan-21 | 01-Jan-25 | Non-Executive Director | | Mr. Huang wishes to devote more time to his other commitments. |
| Law Shing Yvonne Mo Han | 20-Dec-21 | 01-Jan-25 | INED | | |
| Ms. Shing Mo Han, Yvonne | | 01-Jan-25 | INED | | Ms. Shing wishes to devote more time to her other commitments. |
| Yuen Yun Ting | 30-Nov-24 | 20-Dec-24 | CoSec | | |
| Dr. Yang Lu (Alias Patrick Lu) | | 20-Dec-24 | Pres | | Dr. Lu will focus his efforts on business strategies in the US for the Group and has requested to retire from his positions. |
| Leung Leo Ting Cheung | 26-Mar-21 | 30-Nov-24 | CoSec | | |
| Mr. Leung Ting Cheung | | 30-Nov-24 | CoSec | | Resigned. Mr. Leung confirmed that he had no disagreement with the Board and there were no other matters relating to his resignation that need to be brought to the attention of the shareholders of the Company or The Stock Exchange of Hong Kong Limited. |
| Lu Patrick Yang | 15-Oct-20 | 05-Nov-24 | Ch, CEO, Fdr, Pres | | Re-designation as Chief Scientific Officer and from an executive Director to a non-executive Director. Dr. Lu will provide support to Dr. Poon and facilitate a smooth transition. |
| Lu Patrick Yang | 05-Nov-24 | 05-Nov-24 | Non-Executive Director | | Re-designation as Chief Scientific Officer and from an executive Director to a non-executive Director. Dr. Lu will provide support to Dr. Poon and facilitate a smooth transition. |
| Poon Hung Fai | 15-Oct-24 | 05-Nov-24 | ED | | |
| Lu Patrick Yang | | 05-Nov-24 | ED | | Re-designation as Chief Scientific Officer and from an executive Director to a non-executive Director. Dr. Lu will provide support to Dr. Poon and facilitate a smooth transition. |
| Dai Xiaochang | 19-Jul-22 | 21-Oct-24 | ED | | Dr. Dai wishes to devote more time to his other commitments. |
| Evans David Mark | 12-Jul-21 | 20-Jun-24 | ED | | |
| Hua Fengmao | 20-Dec-21 | 20-Jun-24 | INED | | AGM ordinary resolutions regarding, re-election was not passed. |
| Wang Edward Yongxiang | 10-May-24 | 20-Jun-24 | ED | | |
| Dr. David Mark Evans | | 20-Jun-24 | ED | | AGM ordinary resolutions regarding, re-election was not passed. Dr. Evans will remain as the Head of Drug Discovery and Collaboration of the Group |
| Dr. Edward Yongxiang Wang | | 20-Jun-24 | ED | | AGM ordinary resolutions regarding, re-election was not passed. Dr. Wang will remain as the Chief Production Officer of the Group. |
| Yip Nigel Wing Kei | 15-Nov-22 | 31-May-24 | CFO | | |
| Dr. Francois Lebel | | 31-May-24 | Chief Medical Officer | | To devote more time to his other commitments |
| Mr. Yip Wing Kei (Alias Nigel Yip) | | 31-May-24 | CFO | | To devote more time to his other commitments |
| Dai Xiaochang | | 17-May-24 | Chief Strategy Officer | | Due to his personal reasons |
| Molyneaux Michael V | 25-Jan-21 | 30-Nov-23 | ED | | |
| Dr. Michael V. Molyneaux | | 30-Nov-23 | ED | | Dr. Molyneaux wishes to devote more time to his other commitments |
| Zhang Monica Yun | 19-Nov-19 | 31-Aug-23 | CoSec | | |
| Yun Zhang, Monica | | 31-Aug-23 | J-CoSec | | No reasons provided. |
| Poon Hung Fai | 05-Nov-24 | 27-Jun-23 | CEO | | |
| Liu Da | 25-Jan-21 | 30-Sep-22 | Non-Executive Director | | Mr. Liu wishes to devote more time to his other commitments |
| Lai Jiajun | 25-Jan-21 | 31-Aug-22 | Non-Executive Director | | Mr. Lai wishes to devote more time to his other commitments. |
| Dai Xiaochang | 25-Jan-21 | 19-Jul-22 | Non-Executive Director | | Dai has been re-designated from a non-executive Director to an executive Director |
| Wong Eugene Yu Shan | 17-Feb-25 | 12-Jul-22 | INED | | |
| Ghias Mike M | 25-Jan-21 | 12-Jul-21 | Non-Executive Director | | |
| Li Yunchun | 25-Jan-21 | 12-Jul-21 | Non-Executive Director | | |
